1998). Interestingly, histone H1 is very important in stabilizing chromatin higher-order structures, and 30-nanometer fibers form most readily when H1 is present. Processes such as transcription ...

The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.

The study was published under the title 'ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to ...