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Histone H1.2 and PARP1 interact with mutant FUS, contributing to ALS-related neurodegeneration; inhibiting these proteins reduces FUS aggregation. The study's findings are relevant to both familial ...
Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II. The Journal of Cell Biology , 2010; 189 (3): 407 DOI: 10.1083/jcb.201001148 Cite This Page : ...
This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to ...
Scientists have found that the protein histone H1.2 and the enzyme PARP1 could be potential therapeutic targets to decrease neurodegeneration in amyotrophic lateral sclerosis (ALS).
Histone H4 is arguably the easiest histone to work with, possessing the best ionization, ... and also resolved histone H1 phosphorylated isoforms. [85,86] ...
Megha Talati 1, Erin Seeley 2, Kaori Ihida-Stansbury 3, Horace Delisser 3, Hayes McDonald 2, Fei Ye 4, Xueqiong Zhang 4, Yu Shyr 4, Richard Caprioli 2, Barbara Meyrick 5, Altered expression of nuclear ...
A Robust Method for the Purification and Characterization of the Human Histone H1 Variants. Biochemistry. 2018 Dec 26. doi: 10.1021/acs.biochem.8b01060. View All Publications. People. Yael David, PhD.
The linker histone H1 locks the DNA into place and allows the formation of a higher-order structure. Histone deacetylase A class of enzymes that remove acetyl groups from an N-acetyl-lysine amino ...
University of Cologne scientists identified histone H1.2 and PARP1 as potential therapeutic targets in ALS. Inhibiting these proteins reduced neurodegeneration in both human motor neurons and C.
The study, "Histone H1 Phosphorylation Is Associated With Transcription by RNA Polymerases I and II," is available online, or from the U. of I. News Bureau. Journal. Journal of Cell Biology.