2007;27(8):509-531. Antiretroviral drugs (ARVs) can be divided into four different classes according to their modes of action: nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs or ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

Closely related compounds, including nucleotide and nucleobase analogs, share similar therapeutic mechanisms. A significant application of nucleoside analogs is in antiviral therapy. In the late ...

(A) Nucleoside triphosphates serve as a substrate ... releases the free energy needed to drive the incorporation of each nucleotide into the growing DNA chain. The reaction shown on the bottom ...

Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide reverse transcriptase inhibitors (NtRTIs), often all referred to as NRTIs, work by targeting the action of an HIV protein called ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...