Real Madrid has confirmed a second injury to a first team star which will likewise severely affect planning for a Champions League showdown with Manchester City.

Elsewhere among the eight ties, Celtic meet Bayern Munich and there is an all-French contest between minnows Brest and serial domestic champions Paris Saint-Germain. The first legs of the play-off matches will take place on February 11 and 12, with the returns a week later.

Real Madrid had a dreadful evening in Barcelona on Saturday. Not only did they lose 1-0 to Espanyol, but a serious injury blow was also suffered – and given that they are facing a crucial run of