The San Francisco 49ers resume Week 3 of the 2025 NFL preseason hosting the Los Angeles Chargers tonight. Start time, where to watch, stream and NFL schedule.

Brock Purdy, Christian McCaffrey, Trent Williams, Nick Bosa, Fred Warner, George Kittle and Deommodore Lenoir should all be sitting out. A handful of potential starters may suit up to help solidify their status atop the depth chart, but that core group should strictly be focused on the regular season opener Sept. 7.

Uiagalelei played most of the game and finished with 170 yards passing with two touchdowns and one interception. Raheim Sanders led the backfield with 13 carries for 48 yards. Dalevon Campbell was tops on the team with four catches for 73 yards. Oronde Gadsden and Luke Grimm each caught touchdowns.