QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of ...

The Game Matchups Preview series is dedicated to breaking down how the Buffalo Bills match up with their opponent in every ...

When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

One day after waiving wide receiver Ronnie Bell, the 49ers filled his roster spot by promoting cornerback Nick McCloud from ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

Charlotte football ended its season victorious. With the 49ers holding a 29-27 lead during the final minutes, Alabama ...

The San Francisco 49ers battle the Buffalo Bills at 5:20 p.m. PDT on Sunday, Dec. 1 at Highmark  Stadium in Orchard Park, N.Y ...

Here's where every NFL team stands in both conferences in the race to make the playoffs after the Thursday and Friday games ...

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

Buffalo Bills linebacker Matt Milano (58) reacts after a defensive play against the New York Jets during the first quarter of ...