They demonstrate, with cryo-EM-derived structures of two KBTBD4 cancer mutants, how amino-acid sequence variations in KBTBD4 enforce an interaction with the CoREST complex. The structures reveal ...

Glycolic acid is a substance that chemically exfoliates a person’s skin by dissolving dead skin cells and oils. Glycolic acid may also help boost collagen production, and support skin moisture.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Material and Engineering, Sichuan University, Chengdu 610065, P.R. China College of Polymer Science and Engineering, State ...

Prof. John A. Katzenellenbogen’s career has spanned over 55 years and his work has led to 576 publications and 71 reviews and book chapters. His contributions to medicinal chemistry and bioorganic ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

This can sometimes enhance the selectivity of a promiscuous warhead, as in the well-discussed case of enhancing the degradation of the cellular retinoic acid-binding protein (CRABP) over retinoic acid ...