The enzyme MTH1 cleanses the cellular nucleotide pool of oxidatively damaged 8-oxo-dGTP, preventing mutagenesis by this nucleotide. The enzyme is considered a promising therapeutic target; however, ...

The main advantage of the custom nucleotide synthesis is the significant cost reduction over commercial sources, as a result of eliminating the nucleotide purification step.

Cyclic adenosine 3’,5’-monophosphate (cAMP) is a versatile secondary messenger that communicates with Guanine Nucleotide Exchange Factor (EPAC) to transfer cellular signaling and regulates numerous ...

Single-nucleotide polymorphisms in the public domain: how useful are they? Gabor Marth, Raymond Yeh, Matthew Minton, Rachel Donaldson, Qun Li, Shenghui Duan, Ruth Davenport, Raymond D. Miller ...

To verify this effect, the concentration of deoxyribose in the reaction medium was gradually increased and the effect of the extracts in preventing the deoxyribose oxidation by OH decreased in a dose ...

Biotinylated nucleotides have emerged as a powerful tool in molecular biology, enabling researchers to explore genetic materials with unprecedented precision and sensitivity. These modified ...

The geometries corresponding to the first excited singlet state of yA and yT are found to be quasi-planar, while those for yG and yC are nonplanar. In general, binding to deoxyribose will red shift ...