The linker histone H1 family members are a key component of chromatin and bind to the nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both nucleosome structure and ...

Objective: To address key aspects of anti-histone autoimmunity in systemic lupus erythaematosus (SLE), we performed a detailed characterisation of cellular and humoral autoreactivity to histone H1 and ...

Their results indicate that inhibiting those interacting proteins could be a possible therapeutic target for familial cases caused by mutations in FUS. The study was published under the title ‘ALS-FUS ...

University of Cologne scientists identified histone H1.2 and PARP1 as potential therapeutic targets in ALS. Inhibiting these proteins reduced neurodegeneration in both human motor neurons and C.

Scientists have found that the protein histone H1.2 and the enzyme PARP1 could be potential therapeutic targets to decrease neurodegeneration in amyotrophic lateral sclerosis (ALS).

We sought to determine the structural modifications to histone H1 (His-H1) that result from ROS and whether autoantibodies present in lymphoma patients are specific for this modified histone.

Linker histone H1.8 shapes mitotic chromosomes by tuning the number and size of condensin-dependent DNA loops and suppressing condensin and DNA topoisomerase II-dependent individualization.

Citation: Mimura M, Tomita S, Sugai H, Shinkai Y, Ishihara S and Kurita R (2021) Uncharged Components of Single-Stranded DNA Modulate Liquid–Liquid Phase Separation With Cationic Linker Histone H1.

Transposon activation during male gametogenesis is caused by interactions between DNA demethylation and linker histone H1, developmental depletion of which promotes pollen fertility.