Some immunoglobulin heavy-chain V genes were associated with viral infections or autoimmune status, aligning with existing immunological knowledge. SARS-CoV-2-specific BCR sequences from external ...

Three-dimensional genome organization is crucial for the recombination and transcription of immunoglobulin heavy chain (Igh) genes. Here, the authors elucidate how regulatory elements in the 3 ...

In class switch recombination, the gene segments that encode the immunoglobulin heavy chain are rearranged such that antibody of the IgE class is produced. IgE then diffuses locally and enters the ...

Serum for immunoglobulin typing was available in ... Approximately half the patients with γG myeloma were also studied for heavy-chain sub-classes (γd, γG2, γG3 and γG4),* and the frequency ...

Vitamin D (VD) levels are closely related to the occurrence of post-COVID-19 conditions (PCCs), but the specific mechanism is still unclear. Here, a total of 50 PCC patient serum samples were divided ...

A secondary filter step kept only those cells that had both expression and V(D)J information for exactly one heavy and one light chain and were classified ... relative to the bulk of GC B cells.

Immunoperoxidase staining typically shows a lack of K or L light-chain restriction and various heavy chains. The histological differential ... plasma cells. There was no immunoglobulin (Ig)G4 ...

They also show that models learned from nonsynonymous mutations and from out-of-frame sequences are different, prompting new questions about germinal center function. Strengths of the study include an ...

Not far from Jerusalem, archaeologists have discovered the fifth-century burial of a person wrapped in heavy metal chains. But the Byzantine-era grave held another surprise: The person who had ...