2007;27(8):509-531. Antiretroviral drugs (ARVs) can be divided into four different classes according to their modes of action: nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs or ...

Closely related compounds, including nucleotide and nucleobase analogs, share similar therapeutic mechanisms. A significant application of nucleoside analogs is in antiviral therapy. In the late ...

Hepatitis B affects almost 300 million people worldwide, according to GSK, and while nucleoside/nucleotide analogue (NA) drugs to treat it are available – such as Gilead’s polymerase inhibitor ...

GSK’s antisense-based drug for chronic hepatitis B (CHB), bepirovirsen, will get a rapid six-month review from the FDA when it is filed for approval, said the drugmaker this morning. The fast ...

and later dideoxy nucleoside triphosphates, provided the first insights into the sequence of DNA and led to development of the fluorescent nucleotide analogs that enabled whole-genome sequencing.

In collaborative work, Trethera and the Peter Clark Lab at UCLA have shown that when autoreactive T and B cells divide, they activate the TRE-515 target dCK. In those abnormally activated cells, dCK ...

HIV medications stop the virus from making copies of itself. The Food and Drug Administration (FDA) has approved more than 50 HIV medications. HIV is transmitted through contact with blood, semen ...

Dovato (dolutegravir/lamivudine) is a prescription drug that’s used to treat HIV. The drug comes as a tablet that you swallow. It’s usually taken once per day ...

Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have identified ...

School of Physics and Astronomy, Applied Optics Beijing Area Major Laboratory, Center for Advanced Quantum Studies, Beijing Normal University, Beijing 100875, China Laboratory of Soft Matter Physics, ...