How to Train Your Dragon” took flight at the box office this weekend, proving that some remakes still have teeth.

How to Train Your Dragon” is slaying the competition at the box office, opening with $83.7 million this weekend to lead all films in North America, according to industry estimates released Sunday.

The Final Reckoning, however, netted $10.3 million throughout its fourth weekend, and it now stands at $166.3 million domestically. Toss in $340.5 million from overseas markets (including the $21 ...