Active AMPK then inactivates ACC, reducing malonyl-CoA levels. Furthermore, fructose minimally excites anorexigenic POMC neurons while keeping orexigenic AgRP/NPY neuron signals active.

Introduction: Malonyl-CoA decarboxylase deficiency (MLYCDD) is a rare inherited metabolic disorder with multi-organ involvement, causing cognitive impairment, cardiomyopathy, seizures, hypotonia, and ...

Optimization of the curcumin biosynthesis module achieved a curcumin titer of 26.8 ± 0.6 mg/L. Regulating the metabolic fluxes of the β-oxidation pathway and fatty acid elongation cycle and blocking ...

The TIMO circuits, which respond to pyruvate and malonyl-CoA, were engineered to fine-tune the metabolic flux towards IPP synthesis. This remodeling approach resulted in a remarkable increase in ...

Up till now, three known pathways for 3-HP production have been constructed in recombinant organisms, the glycerol pathway, the β-alanine pathway, and the malonyl-CoA reductase (MCR) pathway. The ...

More information: Raffaele Nicastro et al, Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor, Nature Cell Biology (2023). DOI: 10.1038/s41556-023-01198-6 ...

The emerging industrial microorganism Y. lipolytica is naturally endowed with high carbon fluxes towards acetyl-CoA and malonyl-CoA. For example, the overexpression of the endogenous YlPEX10 and ...

Metabolic engineering of Ogataea polymorpha by optimizing the expression of malonyl-CoA reductase and enhancing the supply of precursor malonyl-CoA and cofactor NADPH enables 7.1 g/L 3-HP ...

In all, COA urged UPS to ensure all projects are carried out in compliance with RA No. 9184, act on the causes of suspension of projects and submit all required documents needed to terminate ...