Research studies in cardiovascular epidemiology assessing the relationship between a primary exposure and a health outcome must account for the presence of what are often called third variables, ...

BACKGROUND: Evaluation of whether dyspnea has a cardiac cause is essential. Guidelines from 2016 were reported to result in a high incidence of indeterminate left ventricular (LV) filling pressure. We ...

Independent of etiology, hemolytic diseases are associated with thrombosis, inflammation and immune dysregulation, all together contributing to organ damage and poor outcome. Beyond anemia and the ...

Heart failure with preserved ejection fraction (HFpEF) is a growing health care concern due to its increasing incidence, high morbidity and mortality, and lack of effective treatment options. 1, 2, 3 ...

Pulmonary hypertension (PH) is now defined as mean pulmonary artery pressure >20 mm Hg according to the updated clinical classification from the 6th World Symposium of Pulmonary Hypertension (WSPH) ...

Cardiovascular disease (CVD) is the predominant cause of death globally, accounting for ≈30% of deaths each year. 1 The prevalence of CVD among adults (aged ≥20 years) in the United States was 48.6% ...

Low diet quality in the United States reflects a multitude of factors, 2 of which are food insecurity and nutrition insecurity. Food insecurity is defined as having insufficient access to enough food ...

BACKGROUND: Cerebral small vessel disease (SVD) causes up to 45% of dementias and 25% of ischemic strokes, but the understanding of vascular pathophysiology is limited. We aimed to investigate the ...

Allyn L. Mark—a superb cardiologist, scientist, and mentor—died on April 3, 2025, at the age of 89. He was Editor-in-Chief of Hypertension from 1989 to 1993 (Figure). Figure. Allyn L. Mark. Allyn was ...

Circulation: Heart Failure High-quality mechanistic and clinically relevant science to keep clinicians at the forefront of the latest advancements in the diagnosis and treatment of heart failure ...

BACKGROUND: Penetrance and risk of ventricular arrhythmias (VAs) in arrhythmogenic right ventricular cardiomyopathy (ARVC) are increasingly recognized as being genotype specific. Therefore, ...

A digital twin for precision health is a set of virtual information constructs that mimics the structure, context, and behavior of a human body or health systems (or system‐of‐systems). It is ...