EMBO Press1d
Proteomics and personalized PDX models identify treatment for a progressive malignancy within an actionable timeframe
A precision medicine workflow integrating proteomics and personalized xenograft models was developed and applied to an ...
EMBO Press1d
Dimerization of GAS2 mediates crosslinking of microtubules and F-actin
GAS2 is a cytoskeletal regulator that interacts with both F-actin and microtubules. Here, cryo-EM structures of GAS2 domains ...
EMBO Press9d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
EMBO Press7d
Beyond mitotic arrest: the diverse effects of microtubule-targeting drugs on tumor vasculature
For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...
EMBO Press13d
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
The EMBO Journal9d
Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Actin-based motility is required for the ...
The EMBO Journal2d
HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Diverse sets of progenitors contribute to the ...
The EMBO Journal2d
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metastasis is the primary cause of death in ...
The EMBO Journal2d
Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Single-Molecule Footprinting reveals that RNA ...
The EMBO Journal2d
Liver TET1 promotes metabolic dysfunction-associated steatotic liver disease
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Global hepatic DNA methylation change has been ...
The EMBO Journal8d
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Immune memory plays a critical role in the ...
The EMBO Journal5d
Syndecans and glycosaminoglycans influence B-cell development and activation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Syndecans (SDCs) are ...