The NFL's two best running backs meet Sunday in a potential Super Bowl preview. Seattle, Arizona and San Francisco also have ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

Charlotte football ended its season victorious. With the 49ers holding a 29-27 lead during the final minutes, Alabama ...

Buffalo Bills linebacker Matt Milano (58) reacts after a defensive play against the New York Jets during the first quarter of ...

We can project a good rushing performance again, but when it comes to touchdowns, is it James Cook who scores for the Buffalo ...

The San Francisco 49ers battle the Buffalo Bills at 5:20 p.m. PDT on Sunday, Dec. 1 at Highmark  Stadium in Orchard Park, N.Y ...

Indianapolis Colts (5-7) at New England Patriots (3-9), 8 a.m. HST, CBS ...

As for Purdy’s supporting cast, it will be without some key players. The 49ers will be missing the left side of their ...

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two straight losses sent them below .500.