This third base pair, an artificial addition to nature’s A-T and C-G base pairs, was developed by chemists at the Scripps Research Institute. It has now found what may be its first practical use.

Home Insights Discrimination of Single Base Pair Mismatch. Discrimination of Single Base Pair Mismatch. By Jayne Bates . November 14, 2014. November 15, 2014 (Vol. 34, No. 20) ...

These bases pair up to form two "base pairs" -- the rungs of the DNA ladder -- and they have simply been rearranged to create bacteria and butterflies, penguins and people. Four bases make up all ...

Researchers investigating expanding the DNA “alphabet”—developing artificial bases that can potentially encode more information than the standard A, T, C, and G—have found that DNA polymerase is more ...

This base editor can essentially reverse or rewrite specific base pair mutations. "CRISPR is like scissors, and base editors are like pencils," says David Liu of this new innovation.

But another approach, single base editing, actually converts one base into another—since the bases pair in predictable ways, A to T and G to C, that modification flips a single genetic “bit.” ...

Base Pair Biotechnologies, Inc., The Aptamer Discovery Company™, has completed a $3.2 million series A-3 financing round and opened a new facility.

A Z-T base pair would thus hold DNA's double helix together a bit more than a standard A-T pairing. DNA incorporating Diaminopurine is called Z-DNA.

New crystallography images show that artificial DNA bases take on a surprisingly normal geometry when bound by polymerase. A series of rodent experiments showed that even with abundant food and water, ...

When a modified brick base pairs with its designated spots on the template, it acts as a signal for an enzyme to modify that spot on the template DNA strand as well, “printing” the epigenetic ...