A protein that helps pack DNA into the cell nucleus has an important role in regulating gene activity, scientists report. The researchers found that the protein, histone H1, also takes part in the ...

University of Cologne scientists identified histone H1.2 and PARP1 as potential therapeutic targets in ALS. Inhibiting these proteins reduced neurodegeneration in both human motor neurons and C.

Here we review the major factors regulating the intranuclear mobility and chromatin binding of the linker histone H1, the most abundant family of nucleosome-binding proteins.

The role of histone H1 in male infertility All animals have histones that are specific to the germ line. In Drosophila, BigH1 is expressed in the male and female germ lines.

Immunofluorescence techniques revealed that nuclear expression of histone H1 was decreased and the chromatin was less compact in the IPAH cases than in the controls; furthermore, some cases showed a ...

Epigenetics in Cancer Management The DNA-methylation and histone-modification patterns associated with the development and progression of cancer have potential clinical use.

Histone H4 is arguably the easiest histone to work with, possessing the best ionization, separation and fragmentation properties of any histone at both the polypeptide and intact protein level.

This image shows hematoxylin and eosin staining of sections of wild-type (top row) and H1 triple-knockout (bottom row) embryoid bodies. After 14 days in rotary suspension culture, the wild-type ...

Yael David’s lab develops and applies methods in chemical biology toward studying epigenetic regulation and its correlation with disease states.

A protein that helps pack DNA into the cell nucleus has an important role in regulating gene activity, scientists report. The researchers found that the protein, histone H1, also takes part in the ...