Some immunoglobulin heavy-chain V genes were associated with viral infections or autoimmune status, aligning with existing immunological knowledge. SARS-CoV-2-specific BCR sequences from external ...

Three-dimensional genome organization is crucial for the recombination and transcription of immunoglobulin heavy chain (Igh) genes. Here, the authors elucidate how regulatory elements in the 3 ...

This finding initiated decades of extensive immunochemical studies of immunoglobulin structure ... class switching in the heavy-chain constant region, and increased affinity for antigen in the ...