Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

The 49ers have to come to grips that this running back is injury-prone and cannot be relied upon when the season begins.

The 49ers may provide an indication of how they're feeling about their RB depth in the days ahead. If they sign another ...

Vaughn will solidify the 49ers' backfield depth with Isaac Guerendo (shoulder) and Jordan James (finger) both sidelined for a few weeks. Vaughn spent most of the 2024 season on the 49ers' practice ...

Nearly 40 players are brand new to the 49ers’ roster and poised to make their debut in Saturday’s preseason opener against ...

Jawhar Jordan and Isaac Guerendo combined to anchor a surprisingly stout run game during Jeff Brohm's inaugural season as the head coach of the Cardinals, but both backs were selected in the 2024 NFL ...

Injuries forced running back Isaac Guerendo and fullback Kyle Juszczyk out of Saturday’s practice at 49ers training camp.

In the fourth quarter, Guerendo departed with a foot injury and Shanahan said the 49ers were gathering information and hoping for the best. “I thought Isaac looked real good today,” Shanahan said.

Isaac Guerendo ’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids had a big race. Isaac was 5 or 6 at the time.