The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in the fold?

San Francisco 49ers head coach Kyle Shanahan confirmed Wednesday that the team discussed the possibility of signing ...

Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Here's ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

Head coach Kyle Shanahan and defensive coordinator Nick Sorensen broke down the team's performance against the Green Bay ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

San Francisco 49ers head coach Kyle Shanahan told reporters that star quarterback Brock Purdy will practice with the team ...

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday’s loss at Green Bay ...

Sunday, 8:20 p.m. EST, NBC BetMGM NFL odds: Bills by 7. Series record: Bills lead 7-6. Against the spread: 49ers 4-7, ...

The San Francisco 49ers are 5-6 after a brutal loss to the Green Bay Packers in Week 12. With the playoffs slipping away, ...