The AMPK/malonyl-CoA signalling network. Malonyl-CoA. Malonyl-CoA is both an intermediate in the de novo synthesis of fatty acids and an allosteric inhibitor of carnitine palmitoyltransferase 1 ...

The injections caused a chronic decrease in malonyl CoA levels, which dramatically increased the rats' food intake and led to obesity that was maintained for at least four months.

image: (a) Liquid chromatography–mass spectrometry (LC-MS) was used to detect the content of key intracellular metabolites, including MVA, MEP, pyruvate, and acetyl-CoA.

Metabolic engineering of Ogataea polymorpha by optimizing the expression of malonyl-CoA reductase and enhancing the supply of precursor malonyl-CoA and cofactor NADPH enables 7.1 g/L 3-HP ...

In fatty acid biosynthesis, acetyl-CoA, a metabolite originating mainly from the breakdown of glucose (another important nutrient), is first converted to malonyl-CoA by an enzyme called ACC1 ...

Durch direkte Hemmung von mTORC1 verknüpft Malonyl-CoA den Fettstoffwechsel mit Nährstoffsignalen. Research report 2023 - Max Planck Institute for Biology of Ageing Malonyl-CoA links lipid metabolism ...

Malonyl-CoA is found in bacteria from humans and has important roles in regulating fatty acid metabolism and food intake; it's also an attractive target for drug discovery.

Malonyl CoA is normally transformed into a fatty acid by fatty acid synthase. When C75 blocks fatty acid synthase, levels of malonyl CoA rise. Lane says the hypothalamus may recognize increased levels ...

Further events include an iterative integration of malonyl-Coa carbons into a fatty acid chain which results with the synthesis of a palmitic acid, representing an energy-consuming process.

Assays are underway to determine the effect of the purification procedures upon enzyme activity. Combination of KS, CLF and ACP cell free extracts in the presence of radio-labelled acetyl and malonyl ...

In addition to its effect on PDH, insulin also stimulates the activity of the acetyl-CoA carboxylase (ACC) enzyme. This enzyme is responsible for the conversion reaction from acetyl-CoA to malonyl ...