Active AMPK then inactivates ACC, reducing malonyl-CoA levels. Furthermore, fructose minimally excites anorexigenic POMC neurons while keeping orexigenic AgRP/NPY neuron signals active.

There are hundreds of red dot sights on the market, but Aimpoint’s collaboration with Glock on the new Aimpoint COA isn’t just another repetitious optics launch. The COA, which is only available as a ...

Introduction: Malonyl-CoA decarboxylase deficiency (MLYCDD) is a rare inherited metabolic disorder with multi-organ involvement, causing cognitive impairment, cardiomyopathy, seizures, hypotonia, and ...

Optimization of the curcumin biosynthesis module achieved a curcumin titer of 26.8 ± 0.6 mg/L. Regulating the metabolic fluxes of the β-oxidation pathway and fatty acid elongation cycle and blocking ...

The acetyl-CoA (C) and malonyl-CoA (D) levels were determined by targeted metabolite analysis. Biological replicates, n = 3. (E) Wild-type and NME4 KO Bel-7402 cells were treated with PO for 24 h. ATP ...

The TIMO circuits, which respond to pyruvate and malonyl-CoA, were engineered to fine-tune the metabolic flux towards IPP synthesis. This remodeling approach resulted in a remarkable increase in ...

More information: Raffaele Nicastro et al, Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor, Nature Cell Biology (2023). DOI: 10.1038/s41556-023-01198-6 ...

The emerging industrial microorganism Y. lipolytica is naturally endowed with high carbon fluxes towards acetyl-CoA and malonyl-CoA. For example, the overexpression of the endogenous YlPEX10 and ...

Metabolic engineering of Ogataea polymorpha by optimizing the expression of malonyl-CoA reductase and enhancing the supply of precursor malonyl-CoA and cofactor NADPH enables 7.1 g/L 3-HP ...

The malonyl-CoA decarboxylase gene (MLYCD; MIM 606761) is located on chromosome 16 (16q23.3) (1), containing five exons and three possible promoters. The MLYCD gene encodes malonyl coenzyme A ...