136 Real-world evidence comparing the vitamin-K-antagonist phenprocoumon versus direct oral anticoagulants in patients with atrial fibrillation in Germany ...

Methods The ‘implementation gap’ refers to the difference between the evidence of what works in theory and what is actually delivered in practice. A suite of integrated implementation measures was ...

Most physical tests to identify lumbar-disc herniation show poor diagnostic performance when used in isolation, but findings may not apply to primary care ...

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RRs) use modified systematic review methods to accelerate the review process ...

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RR) use modified systematic review methods to accelerate the review process ...

Clinical trials reduce uncertainties about the benefits and harms of an intervention. Outcomes of interest should be specified before the trial starts (a priori), and clinically relevant to patient ...

56 Evaluating the choosing wisely questions: a pilot study of methods to engage consumers in health decisions across health literacy levels ...

Evidence-based medicine integrates clinical experience with patients' values and the best available evidence.1 In the past, clinicians took responsibility not only for being well informed about the ...

The incorporation of publications that have been retracted is a risk in reliable evidence synthesis. Retraction is an important mechanism for correcting the literature and protecting its integrity.

To practice high quality healthcare, clinicians must be able to diagnose correctly, provide preventative and treatment interventions based on the best available evidence, and ensure decisions are ...

Objectives To compare the effectiveness of different exercise interventions in improving sleep quality and alleviating insomnia severity among patients with insomnia. Design Our study design was a ...

Objectives The anti-Mullerian Hormone (AMH) test is a blood test indicating ovarian reserve (i.e. the number of eggs left in a woman’s ovaries). The test is helpful in assisted reproduction (indicates ...