ATP synthase is an enzyme that catalyzes the formation of the energy storage molecule adenosine triphosphate (ATP) using adenosine diphosphate (ADP) and inorganic phosphate (P i). ATP synthase is a molecular machine. The overall reaction catalyzed by ATP synthase is: ADP + P i + 2H + out ⇌ ATP + H 2 O + 2H + in

Sep 13, 2023 · ATP synthase, also known as F 1 F 0 ATPase or complex V, is the 5th subunit of the oxidative phosphorylation complex. It uses the energy from the electrochemical gradient of protons created by the electron transport chain to produce ATP from ADP.

Jan 28, 2020 · ATP synthase forms ATP from adenosine diphosphate (ADP) and an inorganic phosphate (P i) through oxidative phosphorylation, which is a process in which enzymes oxidize nutrients to form ATP. ATP synthase is found in all lifeforms and powers all cellular activities.

The ATP synthase, also called Complex V, has two major subunits designated F 0 and F 1. The F 0 part, bound to inner mitochondrial membrane is involved in proton translocation, whereas the F 1 part found in the mitochondrial matrix is the water soluble catalytic domain.

Lai et al. determine the complete structures of human ATP synthase in three main rotational states and one substate, providing mechanistic insights into the structure and function of the ATP synthase complexes and laying a foundation for target-based drug discovery.

Oct 21, 2024 · ATP synthase is a complex molecular machine designed to facilitate ATP synthesis. It consists of two main components, the F0 and F1 subunits, each with distinct features and functions. The F0 subunit is embedded within the membrane, forming a channel that allows protons to flow across.

Jan 9, 2025 · Central to ATP production is ATP synthase, an enzyme complex that converts energy stored in proton gradients into chemical energy. This process is fundamental for cellular respiration and photosynthesis, making ATP synthase essential for life.

Mar 7, 2019 · Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria.

Sep 1, 2001 · ATP synthase is a ubiquitous, highly conserved enzyme that catalyses the formation of ATP from ADP and P i using a unique rotary motor mechanism. The enzyme is located in the inner membrane of...

The mitochondrial ATP synthase is a multimeric enzyme complex with an overall molecular weight of about 600,000 Da. The ATP synthase is a molecular motor composed of two separable parts: F1 and Fo. The F1 portion contains the catalytic sites for ATP ...